**Purpose:** Primary mediastinal large B-cell lymphoma (PMBCL) is a rare aggressive lymphoma predominantly affecting young female patients. Large-scale genomic investigations and genetic markers for risk stratification are lacking. **Patients and …
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier *ZNF217* in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of *ZNF217* alterations remain unknown, we …
The climate crisis is probably the greatest threat to global health in the 21st century. Especially mental health is strongly affected by direct and indirect effects of the climate crisis. This article shows the most important connections and …
To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord …
Die Klimakrise ist die wohl größte Bedrohung für die globale Gesundheit im 21. Jahrhundert. Vor allem die psychische Gesundheit ist durch direkte und indirekte Effekte stark von den Auswirkungen der Klimakrise betrof- fen. Dieser Beitrag zeigt die …
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor …